HTA – Health Technology Assessment Programme

Reports from the Health Technology Assessment Programme

The Health Technology Assessment (HTA) programme is part of the National Institute for Health Research (NIHR).  It produces independent research concerning the clinical and cost effectiveness of healthcare treatments.  It produces also information concerning the impact of those treatments for those who plan, provide, or receive care within the National Health Service.  Further information concerning the HTA can be found at   http://www.nets.nihr.ac.uk/programmes/hta.

A selection of information is provided for the following areas:

Lumbar Spine and Lower Extremities

Thoracic Spine

Cervical Spine and Upper Extremities

Chronic Pain

Osteoarthritis

Headaches

Osteoporosis

Research Topics

 

 

Lumbar Spine and Lower Extremities

Lumbar spine

Lewis R, Williams N, Matar HE, Din N, Fitzsimmons D, et al. The clinical effectiveness and cost effectiveness of management strategies for sciatica: systematic review and economic model. Health Technology Assessment 2011;15(39):1-440.  DOI: 10.3310/hta15390.  http://www.hta.ac.uk/1687

Kendrick D, Miller P, Bentley E, et al. The role of radiography in primary care patients with low back pain of at least 6 weeks duration: a randomised (unblinded) controlled trial. Health Technology Assessment 2002;5(30):1-69.  DOI: 10.3310/hta5300. http://www.hta.ac.uk/project/895.asp

Gilbert FJ, Grant AM, Gillan MGC, et al. Does early magnetic resonance imaging influence management or improve outcome in patients referred to secondary care with low back pain? A pragmatic randomised controlled trial. Health Technology Assessment 2004;8(17):1–144.  DOI: 10.3310/hta8170.  http://www.hta.ac.uk/project/897.asp

Lamb SE, Lall R, Hansen Z, et al.  A multicentred randomised controlled trial of a primary-care based cognitive behavioural programme for low back pain. The Back Skills Training (BeST) trial. Health Technology Assessment 2010;14(41):1–281. DOI: 10.3310/hta14410. http://www.hta.ac.uk/project/1358.asp

Hollingworth W et al. The diagnostic utility and cost-effectiveness of selective nerve root blocks in patients considered for lumbar decompression surgery: A systematic review and economic model. http://www.hta.ac.uk/project/2322.asp. The final report will be published in 2013.

 

Lower extremities

Randomised controlled trial of the cost-effectiveness of water-based therapy for lower limb osteoarthritis. Health Technology Assessment 2005;9(31):1–130.   DOI: 10.3310/hta9310 http://www.hta.ac.uk/project/1080.asp

Vale L, Wyness L, McCormack K, et al.  A systematic review of the effectiveness and cost-effectiveness of metal-on-metal hip resurfacing arthroplasty for treatment of hip disease.  Health Technology Assessment 2002; 6(15): 1-117.http://www.hta.ac.uk/execsumm/summ615.shtml

McCarthy CJ,Mills PM,  Pullen R, et al. Supplementation of a home-based exercise programme with a class-based programme for people with osteoarthritis of the knees: a randomised controlled trial and health economic analysis. Health Technology Assessment 2004;8(46):1–76.  DOI: 10.3310/hta8460. http://www.hta.ac.uk/project/999.asp

Black C, Clar C, Henderson R, et al.  The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technology Assessment.  2009;13(52):1–148.   DOI: 10.3310/hta13520. http://www.hta.ac.uk/project/1717.asp

Campbell MK, Skea ZC,  Sutherland AG, et al. Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study). Health Technology Assessment 2010;14(5):1–180. DOI: 10.3310/hta14050.  http://www.hta.ac.uk/project/1448.asp

Clar C, Cummins E, McIntyre L, et al.  Clinical and cost-effectiveness of autologous chondrocyte implantation for cartilage defects in knee joints: systematic review and economic evaluation.  Health Technology Assessment 2005;9(47):1-101 .  http://www.hta.ac.uk/execsumm/summ947.shtml

MW Cooke MW, Marsh JL,  Clark M, et al. Treatment of severe ankle sprain: a pragmatic randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of three types of mechanical ankle support with tubular bandage. The CAST trial.Health Technology Assessment 2009;13(13):1–144. DOI: 10.3310/hta13130.  http://www.hta.ac.uk/1309

 

Thoracic Spine

No relevant reports available currently.

 

Cervical Spine and Upper Extremities

Lamb SE, et al.  Managing Injuries of the Neck Trial (MINT): a randomised controlled trial of treatments for whiplash injuries. http://www.hta.ac.uk/project/1399.asp.  Estimated date of final publication of this trial is March 2013

 

  • Miscellaneous conditions

 

Chronic Pain

McQuay HJ, Moore RA, Ecceleston C, et al.  Systematic review of outpatient services for chronic pain control.  Health Technology Assessment 1997;1(6):1–137. DOI: 10.3310/hta1060.  http://www.hta.ac.uk/project/913.asp

 

Osteoarthritis

Randomised controlled trial of the cost-effectiveness of water-based therapy for lower limb osteoarthritis. Health Technology Assessment 2005;9(31):1–130.   DOI: 10.3310/hta9310 http://www.hta.ac.uk/project/1080.asp

McCarthy CJ,Mills PM,  Pullen R, et al.Supplementation of a home-based exercise programme with a class-based programme for people with osteoarthritis of the knees: a randomised controlled trial and health economic analysis.Health Technology Assessment  2004;8(46):1–76.  DOI: 10.3310/hta8460. http://www.hta.ac.uk/project/999.asp

Black C, Clar C, Henderson R, et al.  The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation.Health Technology Assessment.  2009;13(52):1–148.   DOI: 10.3310/hta13520. http://www.hta.ac.uk/project/1717.asp

Campbell MK, Skea ZC,  Sutherland AG, et al. Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study).Health Technology Assessment 2010;14(5):1–180. DOI: 10.3310/hta14050.  http://www.hta.ac.uk/project/1448.asp

Chen Y-F, Jobanputra P, Barton P, et al.  Cyclooxygenase-2 selective non-steroidal anti-inflammatory (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis or rheumatoid arthritis: a systematic review and economic evaluation. Health Technology Assessment 2008;12(11):1–178.  DOI: 10.3310/hta12110. http://www.hta.ac.uk/project/1383.asp.   Guidance is available also on the NICE website http://www.nice.org.uk/Guidance/TA27

 

Headaches

Royle P, Cummins E, Walker C, et al.  Evidence review group report: Botulinum toxin type A for the prophylaxis of headaches in adults with chronic migraine.  http://www.hta.ac.uk/erg/reports/2643.pdf

 

Osteoporosis

Kanis JA, Stevenson M, McCloskey EV, et al.  Glucocorticoid-induced osteoporosis: a systematic review and cost-utility analysis.  Health Technology Assessment 2007;11(7):1-258.  http://www.hta.ac.uk/execsumm/summ1107.shtml

 

Research Topics

Dalziel K, Round A, Stein K, et al.  Do the findings of case series studies vary significantly according to methodological characteristics?  Health Technology Assessment 2005;9(2):1–166.  http://www.hta.ac.uk/execsumm/summ902.shtml

Bartlett C, Doyal L, Ebrahim S, et al.  The causes and effects of socio-demographic exclusions from clinical trials.  Health Technology Assessment 2005;9(38):1-171. http://www.hta.ac.uk/execsumm/summ938.shtml